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Longevity

Dr. David Sinclair, a renowned researcher in the field of aging has conducted extensive studies on Nicotinamide Mononucleotide (NMN) and its potential to extend lifespan.

In a 2023 interview, Dr. Sinclair confirmed that NMN supplementation increased lifespan in mice, indicating promising implications for human aging.

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David Sinclair being interviewed by Peter Diamandis at the Abundance360 Summit.

Harvard’s David Sinclair: NAD⁺ Precursor NMN Increases Lifespan in Unpublished Study

In a recent interview, Harvard scientist Dr. David Sinclair revealed that his lab has data showing NMN prolongs mouse lifespan, but will it join the ranks of the most reliable life-extending agents?

Key Points:

  • In two of his latest interviews, Sinclair mentions his unpublished data showing that NMN extends mouse lifespan.
  • Mouse life extension results are the closest we have to human life extension results.
  • Anti-aging agents rapamycin, acarbose, captopril, and glycine have reliably been shown to increase mouse lifespan/li>

    David Sinclair’s research at Harvard Medical School focuses on finding ways to slow the aging process. Currently, there exist a select few anti-aging agents that are capable of doing so, and nicotinamide mononucleotide (NMN) may now be one of them.

    On June 23, 2023, Sinclair appeared on the World of DaaS podcast with Auren Hoffman. During the conversation, Sinclair said,

    “In fact, we’ve only just recently found [NMN] extends mouse’s lifespan. I haven’t published that yet.”

    This means that Sinclair and his colleagues will soon publish the first study to show that NMN extends the lifespan of mice.

    In a more recent interview with Dr. Peter H. Diamandis on August 24, 2023, Sinclair also mentioned the unpublished data. When speaking of the benefits of NMN, he said,

    This means that Sinclair and his colleagues will soon publish the first study to show that NMN extends the lifespan of mice.

    In a more recent interview with Dr. Peter H. Diamandis on August 24, 2023, Sinclair also mentioned the unpublished data. When speaking of the benefits of NMN, he said

    “What we saw in the mice, which was — haven’t published this but — increased lifespan, improved health, less frailty, protection from radiation….”

    From this interview we get a bit more information with Sinclair mentioning that NMN not only increases lifespan but also improves health, reduces frailty, and protects against radiation.

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    David Sinclair being interviewed by Peter Diamandis at the Abundance360 Summit.

    Previous Studies Showing Boosting NAD+ Increases Mouse Lifespan

    When it comes to extending mouse lifespan by boosting NAD+, no published data has yet shown that NMN increases the lifespan of naturally aged mice. However, NMN is not the only compound capable of countering age-related NAD+ decline. The NAD+ booster nicotinamide riboside (NR) has been shown to increase the lifespan of naturally aged mice by 5%.

    Aside from NAD+ precursors like NMN and NR, NAD+ can also be boosted by compounds that stop its age-related increase in degradation. It is thought that one of the primary reasons for age-related NAD+ decline is an increase in the activity of an enzyme called CD38. Indeed, blocking CD38 with a small molecule called 78c was shown to increase mouse lifespan by 14%.